ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease
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منابع مشابه
ABCB1-C3435T polymorphism and breast cancer risk: a case-control study and a meta-analysis.
PURPOSE To investigate the association of ABCB1-C3435T transition with breast cancer risk which was followed by a meta-analysis. METHODS In a case-control study we collected blood samples from 290 women (including 150 breast cancer patients and 140 healthy controls). ABCB1-C3435T genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. ...
متن کاملIncreased Risk for Congenital Heart Defects in Children Carrying the ABCB1 Gene C3435T Polymorphism and Maternal Periconceptional Toxicants Exposure
BACKGROUNDS The etiology of congenital heart defect (CHD) is commonly believed to involve the interaction of multiple environmental and genetic factors. This study aimed to explore the joint effects of the ABCB1 gene C3435T polymorphism and maternal periconceptional toxicants exposure on the CHD risk in a Han Chinese population. METHODS An age and gender matched case-control study with standa...
متن کاملAssociation of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head
BACKGROUND AND OBJECTIVE The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclus...
متن کاملThe effect of ABCB1 C3435T polymorphism on pharmacokinetics of tacrolimus in liver transplantation: a meta-analysis.
OBJECTIVES The effect of ABCB1 C3435T SNP on the pharmacokinetics of immunosuppressive drug tacrolimus in different studies was conflicting. So a meta-analysis was employed to study the correlation of ABCB1 C3435T SNP and the pharmacokinetics of tacrolimus at different post-transplantation times. METHOD Several studies about ABCB1 C3435T polymorphism and the pharmacokinetics of tacrolimus wer...
متن کاملC3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers.
The functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the ABCB1 gene encoding the xenobiotic transporter P-glycoprotein (P-gp) may influence susceptibility to several diseases, as well as the clinical outcome of treatment with P-gp substrates. Exposure to environmental chemicals is thought to be involved in peptic ulcer pathogenesis and then later in stomach cancer developmen...
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ژورنال
عنوان ژورنال: Journal of Molecular Neuroscience
سال: 2014
ISSN: 0895-8696,1559-1166
DOI: 10.1007/s12031-014-0427-z